Promethazine is metabolized from the liver to various compounds; the sulfoxides of promethazine and N-demethylpromethazine are definitely the predominant metabolites appearing from the urine.

The combination of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric patients below 6 years of age. Concomitant administration of promethazine merchandise with other respiratory depressants has an association with respiratory melancholy, and sometimes Loss of life, in pediatric people. The association does circuitously relate to individualized excess weight-dependent dosing, which could in any other case allow safe administration.

Anticholinergics– Concomitant utilization of other brokers with anticholinergic Attributes ought to be undertaken with warning.

Pregnancy Tests: Diagnostic pregnancy exams dependant on immunological reactions in between HCG and anti-HCG may possibly result in false-negative or Phony-constructive interpretations.

Promethazine: Promethazine is a phenothiazine spinoff which differs structurally from the antipsychotic phenothiazines by the presence of a branched aspect chain and no ring substitution.

Narcotic analgesics cross the placental barrier. The closer to shipping and also the much larger the dose employed, the greater the possibility of respiratory melancholy during the newborn. Narcotic analgesics needs to be averted for the duration of labor if delivery of the premature toddler is anticipated.

Promethazine HCl and Codeine Phosphate Oral Alternative really should be utilised with caution in patients with bone- marrow melancholy. Leukopenia and agranulocytosis have already been reported, ordinarily when promethazine has long been Utilized in Affiliation with other identified marrow-harmful agents.

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Fetal/Neonatal click here Adverse Reactions Extended utilization of opioid analgesics for the duration of pregnancy for clinical or nonmedical needs may lead to Bodily dependence inside the neonate and neonatal opioid withdrawal syndrome shortly after delivery.

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A pharmacist can endorse an proper measuring machine and can provide Recommendations for measuring the proper dose.

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Promethazine HCl Oral Answer needs to be applied all through pregnancy provided that the potential advantage justifies the prospective chance on the fetus.

Your Health care supplier could do blood checks to check for adrenal gland difficulties. Phone your Health care company immediately if you have any of these signs: